Implications for the mechanism of pathogenesis in Alzheimer's disease". Research suggests that soluble oligomeric forms of the peptide may be causative agents in the development of Alzheimer's disease. Dual polarisation interferometry is an optical technique which can measure early stages of aggregation by measuring the molecular size and densities as the fibrils elongate. The Journal of Biological Chemistry. The gene for the amyloid precursor protein is located on chromosome 21 , and accordingly people with Down syndrome have a very high incidence of Alzheimer's disease. Applied Biochemistry and Biotechnology. A recent study suggested that APP and its amyloid potential is of ancient origins, dating as far back as early deuterostomes. As a result, amyloid beta promotes depolarization of the synaptic membrane, excessive calcium influx and mitochondrial impairment. Journal of Neural Transmission.
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